Crystallography

The Crystallography Facility enables you to apply the methods of X-ray crystallography to your biological questions. We can offer both state of the art equipment and expert advice and training in the use of crystallography for structural biology.

The Crystallography Facility enables you to apply the methods of X-ray crystallography to your biological questions. We can offer both state of the art equipment and expert advice and training in the use of crystallography for structural biology.

The Crystallography Facility enables you to apply the methods of X-ray crystallography to your biological questions. We can offer both state of the art equipment and expert advice and training in the use of crystallography for structural biology.

The Crystallography Facility enables you to apply the methods of X-ray crystallography to your biological questions. We can offer both state of the art equipment and expert advice and training in the use of crystallography for structural biology.

In the Crystallography Facility we offer a full suite of facilities and support to enable you to study the structure of both soluble and membrane-associated proteins by means of X-ray crystallography. Equipment, facilities and advice are available to help you through the whole process from starting to a protein sample to finishing with interpreting a structural model.

We have two robots to aid in preparing crystallisation trials, a TTP Labtech Mosquito suitable for a wide range of vapour diffusion experiments and an Art Robbins Gryphon specialised for the cubic phase crystallisation of membrane proteins.

To help you follow the progress of your crystallisation trials we have two robotic crystallisation incubators that store experiments at 4 °C or 18 ºC and automatically take pictures using both visible and UV light that you can inspect from your own computer using a web browser. We also have a selection of bench top microscopes that you can use both to harvest crystal once they have grown.

We also organise time at large scale synchrotron facilities such as Diamond and the ESRF and provide assistance in using them to obtain X-ray diffraction from your crystals. Once this has been achieved we also provide computing assistance to help you analyse your data and solve your structure.

If you have any questions please do not hesitate to contact Ed (edward.lowe@bioch.ox.ac.uk)

Advanced Fluorescence Microscopy

Micron Oxford is an advanced Bioimaging Unit developing and applying cutting edge technologies as well as providing diverse advanced imaging facilities. They help users perform optimum imaging experiments to address their biological questions, offering advice training and advice on experimental design, specimen preparation, image analysis and data storage.

Advanced Proteomics Facility

The Advanced Proteomics Facility provides access to the latest proteomics technologies. It’s equipped with a wide range of mass spectrometry instrumentation, HPLC fractionation systems, sample preparation technologies and data analysis software. We provide protein, protein complex, proteome identification as routine services.

NMR Spectroscopy

Solution-state Nuclear Magnetic Resonance (NMR) spectroscopy is a method that provides detailed information about the structure, dynamics and interactions of biological macromolecules under conditions that can mimic the cellular environment.

Molecular Biophysics

We offer a range of techniques to study macromolecules and macromolecular complexes. These include analytical ultracentrifugation, differential scanning calorimetry, electrospray ionization mass spectrometry, isothermal titration calorimetry and surface plasmon resonance. All users must be registered with Dr David Staunton and receive any necessary training.

Visualising how a malaria parasite invades human red blood cells

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Members of the Higgins group have made new discoveries about how malaria parasites get inside our red blood cells which might help them to design new vaccines

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The lab of Fanni Gergely has developed a new affinity-based method that allows rapid isolation of centrosomes for proteomic profiling

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A new study published in the journal Science Advances sheds light on how Gram-negative bacteria like E. coli construct their outer membrane to resemble body armour, which has far-reaching...

A new study published in the journal Science Advances sheds light on how Gram-negative bacteria like E. coli construct their outer membrane to resemble body armour, which has far-reaching implications for the development...

A new study published in the journal Science Advances sheds light on how Gram-negative bacteria like E. coli construct their outer membrane to resemble body armour, which has far-reaching implications for the development of antibiotics

A collaborative study between Oxford, Glasgow and UKHSA discovers unexpected differences in the replication of SARS-CoV-2 variants of concern

A new study reveals differences in replication rates of SARS-CoV-2 variants of concern using single molecule RNA...

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One cell, two genomes? Coordination between mitochondria and the nucleus in cancer

New paper from the Peter Sarkies research group

New therapeutic possibilities at the ‘heart’ of SARS-CoV-2 life cycle

A team led by researchers at the University of Oxford, University of Glasgow, and University of Heidelberg, uncovers...

A team led by researchers at the University of Oxford, University of Glasgow, and University of Heidelberg, uncovers the interactions that SARS-CoV-2 RNA establishes with the host cell,...

A team led by researchers at the University of Oxford, University of Glasgow, and University of Heidelberg, uncovers the interactions that SARS-CoV-2 RNA establishes with the host cell, paving the way for the development...

A team led by researchers at the University of Oxford, University of Glasgow, and University of Heidelberg, uncovers the interactions that SARS-CoV-2 RNA establishes with the host cell, paving the way for the development of new therapeutic strategies

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A new study from the Newstead group, published in Nature, reveals the structure of the folate transporter, laying...

A new study from the Newstead group, published in Nature, reveals the structure of the folate transporter, laying the foundation for developing targeted anticancer drugs

Crystallography

Facility information

Other facilities

Advanced Fluorescence Microscopy

Advanced Proteomics Facility

NMR Spectroscopy

Molecular Biophysics

Latest discoveries

Visualising how a malaria parasite invades human red blood cells

COVID Moonshot initiative identifies novel antiviral compound

Armed to the hilt: Study solves mystery behind bacteria’s extensive weaponry

Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method

Scientists Discover Enzyme That Turns Air Into Electricity, Providing A New Clean Source Of Energy

Research reveals the first molecular understanding of BIRC6 – an essential regulator of cell death

New Publication: "GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation"

Bacterial armour plating has implications for antibiotics

A collaborative study between Oxford, Glasgow and UKHSA discovers unexpected differences in the replication of SARS-CoV-2 variants of concern

One cell, two genomes? Coordination between mitochondria and the nucleus in cancer

New therapeutic possibilities at the ‘heart’ of SARS-CoV-2 life cycle

Structure of the folate transporter paves the way for improved anticancer drugs