Professor Bela Novak (1956–2025): A Life of Scientific Discovery in Numbers
It is with profound sorrow that we announce the passing of Professor Béla Novák, a distinguished scientist, mentor, and friend who passed away in February 2025. His loss is deeply felt by all who had the honour of knowing him.
Professor Béla Novák
Professor Novák was a highly respected computational and systems biologist, known for his pioneering work on the eukaryotic cell cycle. His research spanned various organisms, from yeasts and early embryos to human cells, and transformed our understanding of the fundamental principles governing cell division and regulation. Through his innovative use of mathematical modelling, he provided groundbreaking insights into the dynamics of biochemical networks, influencing both theoretical biology and biomedical research. By developing nonlinear differential equation models, he elucidated how bistable switches orchestrate critical cell cycle decisions, ensuring transitions are both decisive and irreversible.
Born in 1956, Professor Novák’s scientific journey began in Hungary, where he trained as a chemical engineer before transitioning to biology. In the late 1980s, Béla collaborated with Murdoch Mitchison in Edinburgh, exploring the fission yeast cell cycle at a pivotal moment in modern cell cycle research. This partnership laid the foundation for his transformative collaboration with John Tyson in the early 1990s. Together, they embarked on a pioneering endeavour to construct accurate mathematical models of molecular networks that drive cell cycle progression. Their groundbreaking work culminated in the 1993 publication of the first realistic computational model detailing cell cycle controls, particularly emphasizing DNA synthesis and mitosis in frog embryos and extracts. Béla’s commitment to fostering a collaborative research environment led to numerous partnerships with experimental groups, ensuring that his theoretical models were grounded in empirical data. His research advanced the field of systems biology and encouraged a generation of scientists to adopt quantitative approaches in biological research. Since 2007 he was Professor of Integrative Systems Biology in the Department of Biochemistry at Oxford, where his work not only advanced our knowledge of cellular processes but also inspired a new generation of young scientists who continue to build upon his legacy. He was a passionate teacher and mentor, known for his generosity, intellectual rigor, humility, and ability to make complex concepts accessible to students and colleagues alike. He will be missed by all.
Beyond his academic achievements, Béla was a devoted husband, father, and friend. His love for his family was evident in everything he did, and despite his demanding career, he always prioritized time with his loved ones. His warmth, kindness, and unwavering support made a lasting impact on those who had the privilege of knowing him.
Professor Novák’s important contributions to science will endure, but he will be remembered just as much for his kindness, integrity, and the profound influence he had on those around him. He leaves behind a lasting legacy in both his professional and personal life.
He is survived by his loving family, friends, and colleagues who will miss him dearly. A memorial will be held in his honour at the University of Oxford, where his life, work, and the remarkable person he was will be celebrated by all who had the privilege of knowing him.
Béla, your wisdom, generosity, and brilliance will not be forgotten.
Francis Barr
26th February 2025
